Faculty of Basic Medical Sciences: Recent submissions
Voici les éléments 41-60 de 153
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INFLUENCE OF FREE RADICAL -MEDIATED MEMBRANE DAMAGE ON ERYTHROCYTE Ca²⁺-HOMEOSTASIS IN CERTAIN PATHOLOGICAL STATES
(1990-11)The possible nature of toxic oxygen from radical species generated in vivo under pathological conditions as well as the relationship between oxygen free radicals and/or lipid peroxidation and the abnormal regulation of ... -
A STUDY OF THE EFFECT OF THE AFLATOXINS ON BLOOD CLOTTING
(1967-06)The structural configurations of the synthetic coumarins have been shown to be of major importance in their action on blood clotting. In view of the similarities in the structures of the synthetic coumarins and the aflatoxins, ... -
CEMENT DUST INDUCED-IMMUNOTOXICOLOGICAL AND CELLULAR RESPONSES IN LUNG CELLS
(2013-05)Recent epidemiological studies revealed that exposure to cement dust is associated with development of laryngeal cancer and other metal related diseases. The mechanism of injury to lung cells and disease development by ... -
GENETIC DIVERSITY AND CORECEPTOR USAGE OF HIV-1 STRAINS AMONG INFECTED INDIVIDUALS PRESENTING AT A VOLUNTARY COUNSELLING AND TESTING CENTRE IN IBADAN, NIGERIA
(2013)Molecular analyses of Human Immunodeficiency Virus (HIV) have shown great genetic diversity among strains of the virus. The diversity has implications on efficiency of its transmission, pathogenesis, diagnosis, vaccine ... -
GENETICS AND PATHOGENICITY OF THREE H5N1 AVIAN INFLUENZA A VIRUS ISOLATES OF CHICKEN IN SOUTHWESTERN NIGERIA
(2011-09)Highly Pathogenic Avian influenza A (HPAI) H₅NI outbreak has been reported in several African countries including Nigeria. The outbreak continues to pose a risk to human health and livelihood. The genetics and pathogenicity ... -
RISK FACTORS AND EFFECTS OF ANTIMALARIAL DRUGS ON PLASMODIUM FALCIPARUM GAMETOCYTAEMIA IN NIGERIAN CHILDREN
(2007-07)Gametocytes are the sexual forms of Plasmodium species that are essential for the transmission of malaria. However, there is little information on the factors that influence their generation or carriage, a measure of ... -
HYPOLIPIDAEMIC, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF Persea americana (Lauraceae) LEAF EXTRACTS IN RATS)
(2010-05)Hyperlipidaemia and oxidative stress are important factors in the pathogenesis of chronic degenerative and inflammatory diseases. Persea americana (Lauraceae) has been widely used in ethnomedicine in the treatment of various ... -
CYTOTOXICITY OF HEXAVALENT CHROMATE COMPOUNDS IN CH310T1/2 CELLS AND CYTOMODULATION BY SODIUM ARSENITE AND METHANOL EXTRACT OF Rauvolfia vomitora (Afzel) IN MICE
(2015-02)Exposure to certain hexavalent chromate compounds (HCC) causes lung and colon cancers. Their mechanisms of cytotoxicity are unclear, but believed to be affected by ascorbate and particle size. However, their role is not ... -
PROTECTIVE EFFECTS OF KOLAVIRON AND QUERCETIN ON ATRAZINE-INDUCED NEURONAL AND TESTICULAR DAMAGE IN CELL LINES AND RATS
(2012-10)Neurodegenerative diseases and decline in male fertility are reported to be associated with exposure to environmental chemicals. Many agrochemicals including atrazine are known to induce reproductive and neuronal toxicity. ... -
ANTICANCER, ANTIOXIDANT AND IMMUNO-MODULATORY EFFECTS OF "ACACIA HONEY" IN SOME CANCER CELL LINES
(2014-11)Cancer is one of the leading causes of death worldwide. Cancer curative properties of honey have been documented. However, there is dearth of information on the exact mechanism of anticancer effect of honey. This study was ... -
LANDFILL LEACHATE-INDUCED OXIDATIVE DAMAGE IN RAT AND AFRICAN CATFISH
(2014-06)Landfill leachate poses potential health hazards for man and his environment. Leachates can generate free radicals in exposed tissues. Free radicals may cause DNA damage and oxidative stress associated with many disease ... -
ANTIOXIDANT AND CHEMOPROTECTIVE PROPERTIES OF VERNONIA AMYGALINA DEL. LEAF EXTRACT IN EXPERIMENTAL MODELS OF HEPATOTOXICITY AND HUMAN ERYTHROCYTE LYSIS
(2010)Reactive oxygen species (ROS) have been implicated in the etiology of several pathological and degenerative diseases. Protective effect of natural products possessing antioxidant properties has played very crucial role in ... -
GASTRIN CONTENT AND ACTIVITY IN SOME RUMINANTS AND SOME EQUINES
(1973-06)Attempts were made to extract gastrin from the cardiac, fundic pyloric, duedenal osecal and colonic mucosa of goats, sheep, cattle, male and female donkeys, using a modification of the gastrin extraction method introduced ... -
THE INFLUENCE OF CHLOROQUINE PHOSPHATE ON MALE REPRODUCTIVE FUNCTIONS
(1991-09)The influence of Chloroquine phosphate on Male reproductive functions in the adult and pre-pubertal rats was studied. Chloroquine phosphate dissolved in distilled water was administered intraperitoneally daily to the rats ... -
RIFT VALLEY FEVER VIRUS IN NIGERIA: COMPARATIVE EXPERIMENTAL INFECTIONS OF THREE BREEDS OF INDIGENOUE SHEEP AND SERO-SURVEY OF HUMAN AND ANIMAL POPULATIONS
(1990-09)Electron microscopic examination by negative staining and antigen controlled immunodiagnosis techniques on the Zinga virus used for this study showed that it is a strain of Rift Valley fever (RVF) virus. This is based on ... -
MODULATING EFFECT OF POLYCLONAL ANTIBODIES AGAINST AFLATOXIN B₁ MACROMOLECULAR COMPLEXES ON AFLATOXIN INDUCED HEPATOCARCINOGENESIS
(1990-11)Polyclonal immunoglobulin G antibodies were raised in adult male albino rabbits against aflatoxin B₁-bovine serum albumin, aflatoxin B₁-histone H₁ and aflatoxin B₁-microsomal proteins complexes after a single intradermal ... -
HORMONE AND DRUG STIMULATION OF TESTOSTERONE SECRETION IN THE RAT LEYDIG CELL
(1995-07)The steroidogenic response of rat Leydig cell to gonadotrophin and prolactin was used to modify an in vitro experimental model for studies an the effect of some medicinal extracts on testosterone secretion. The crude ... -
ANTIGENIC ANALYSIS OF NIGERIAN STRAINS OF WEST NILE VIRUS
(1975-03)Sero-immunological methods were employed to investigate the antigenic relationships among West Nile virus isolates originating in Nigeria. The techniques included neutralization test in new born mice, complement fixation, ... -
EVALUATION OF EXTRACTS OF MORINDA LUCIDA AND OTHER DRUGS FOR ANTIMALARIA ACTIVITY
(1988-09)The impact of the problem of drug resistance on the capacity to provide adequate treatment for malaria is becoming more marked as more countries try to provide treatment facilities for their entire population. The need for ... -
HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 SEROTYPES AND SOME ASPECTS OF PHENOTYPIC PROPERTIES OF THE VIRUS ISOLATES IN NIGERIA
(1999-08)Human Immunodeficiency Virus (HIV) is a retrovirus aetiologically and epidemiology associated with the Acquired Immunodeficiency Syndrome (AIDS). The prevalence of HIV infection and the disease and incidence of AIDS are ...
