Faculty of Basic Medical Sciences: Recent submissions
Now showing items 21-40 of 153
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EFFECTS OF VITAMIN SUPPLEMENT ON PLASMA HOMOCYSTEINE AND APOLIPOPROTEIN A₁ LEVELS IN CHILDREN WITH NEPHROTIC SYNDROME IN IBADAN, NIGERIA
(2013-04)Nephrotic Syndrome (NS), a condition characterized by proteinuria, hypoproteinaemia, and hypercholesterolaemia resulting from damage to the kidneys' glomeruli blood vessel, is a common childhood disease worldwide. Elevated ... -
THE ROLE OF KUPFFER CELLS IN ETHANOL AND AFLATOXIN B₁-INDUCED p53 GENE MUTATION IN HEPATOCARCINOGENESIS
(2009-06)Kupffer cells (KC) play an important role in hepatic homeostasis, and in acute and chronic response of the liver to endotoxins. The KC also mediate the release of cykokines and reactive oxygen species (ROS) involved in ... -
ANTIGENOTOXIC ACTIVITIES OF EXTRACTS OF SPONDIAS MOMBIN L.(ANACARDIACEAE) AND CHROMOLAENA ODORATA L. (ASTERACEAE)
(2010-10)Spondias mombin (Anarcadiaceae) and Chromolaena odorata (Asteracea) are common tropical shrubs. Different parts of the plants are used locally as antibacterial, anthelmintic agents and in the treatment of ulcerative wounds ... -
PROTECTIVE EFFECTS OF METHANOL EXTRACT OF Chasmanthera dependens HOCHST STEMON ACIDIFIED ETHANOL-AND INDOMETHACIN-INDUCED GASTRIC ULCER AND APOPTOSIS IN MALE WISTAR RATS
(2015)Gastric ulceration is a common clinical problem which may results from incessant use of drugs. Chasmanthera dependens possesses analgesic effects in experimental rats and anecdotal report exit on its gastric ulcerogenic ... -
PROTECTIVE EFFECTS OF QUERCETIN AND RUTIN ON SULFASALAZINE-INDUCED TESTICULAR TOXICITY AND APOPTOSIS IN MALE WISTAR RATS
(2015-08)Sulfasalazine is used as a therapy for inflammatory bowel diseases. High doses may be associated with male infertility; reversible only on drug withdrawal. Sulfasalazine metabolism generates oxidative stress as a mechanism ... -
BIOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF METHANOLIC LEAF EXTRACT OF SPONDIAS MOMBIN LINN
(2011)Spondias mombin is used traditionally in Nigeria for the management of malaria, diarrhoea and microbial infections but there is insufficient data from pharmacological investigations on its properties. The effects of the ... -
EVALUATION OF ANTIPSYCHOTIC EFFECTS OF METHYL JASMONATE IN MICE
(2017-01)Psychosis is a chronic neurological disorder that impairs the quality of life of the patients and remains a major health challenge worldwide. Current drugs used to manage psychosis are expensive and only provide symptomatic ... -
PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON SOME CONSTITUENTS OF VERNONIA AMYGDALINA
(1995-11)Some saponins and flavonoids occuring in the leaves of Vernonia amygdalina (Compositae) and the biological response they elicited were investigated. C18 fractionation of a 169 g methanolic extract of the leaves using 30-70% ... -
EFFECTS OF THE LEAF DECOCTION OF MOMORDICA CHARANTIA (BITTER LEMON) ON MITOCHONDRIAL MEMBRANE PERMEABILITY TRANSITION PORE AND FERTILITY IN MALE ALBINO RATS
(2011-06)Certain anti-cancer agents act by inducing the intrinsic pathway of apoptosis which is mediated by the release of cytochrome C when the Mitochrondial Membrane Pemeability Transition (MMPT) pore opens. Several studies have ... -
PROTECTIVE ROLE OF PROTOCATECHUIC ACID IN NEVIRAPINE-INDUCED HEPATOTOXICITY AND APOPTOSIS IN MALE WISTER RATS
(2015-08)Nevirapine is a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) used in HIV-I treatment. Although efficacious, it produces toxic responses such as hepatotoxicity which is characterised by generation of free radicals. ... -
MECHANISM OF ANTI-DIABETIC ACTIVITIES OF Musa sapientum LEAF EXTRACT IN RATS TREATED WITH ALLOXAN
(2014)Diabetes mellitus results from necrosis of pancreatic β-cell and insulin resistance at the cellular level. Musa sapientum has been shown to possess anti-diabetic properties. However, the mechanism of its action is unknown. ... -
ANTIOXIDANT AND ANTICLASTOGENIC POTENTIALS OF METHANOLIC EXTRACT OF DEFATTED HOLARRHENA FLORIBUNDA LEAVES (G.DON)
(2010-11)Holarrhena floribunda is a widely used plant in herbal formulations against number of disease in Nigeria. There is no sufficient information on the scientific basis for its use. Methanolic leaf extract of defatted H.floribunda ... -
EVALUATION OF MECHANISMS UNDERLYING ANTIDEPRESSANT-LIKE EFFECT OF METHYL JASMONATE IN MICE
(2017-11)Depression is a chronic, recurrent and severe disease that affects millions of individuals worldwide and impairs the quality of life of the patients. The clinical efficacy of existing antidepressants has been compromised ... -
EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITIES OF EXTRACTS AND FLAVONOID-RICH FRACTION FROM Ocimum gratissimum LINN.(LAMIACEAE) LEAF
(2017-08)Inflammatory responses are among causes of ill health, impaired quality of life and untimely death. Naturally occurring phenolics are sale phytochemicals that provides combinatorial multitargeted therapy in chronic ... -
CYTOREMEDIATION OF SODIUM ARSENTIE-INDUCED TOXICITIES BY EXTRACT OF adansonia digitata LINN. IN CELL LINES AND WISTAR RATS
(2018-01)Arsenicals are proven human and animal environmental clastogens and carcinogens. Research has focused on ameliorating their toxicities using medicinal plants such as Adansonia digitata (AD). Although, there are available ... -
EFFECTS OF METHANOL EXTRATOF plukenstia conophora SEED AND 4H-PYRAN-4-ONE2,3-DIHYDRO-3,5-DIHYDROXY-6-METHYL-ON CADIUM CHLORINE-INDUCED RESPODUCTIVE TOXICITY IN WISTAR RATS
(2017-07)Infertility is a current global issue with diverse treatments. However, many infertile people especially in developing countries resort to folkloric treatment due to unyielding results from synthetic medications. ... -
EVALUATION OF THE ANTISPYCHOTIC PROPERTY OF MORIN AND ITS MECHANISMS OF ACTION IN EXPERIMENTAL MICE
(2018-06)Psychosis is a chronic neuropsychiatric disease characterised by severe behavioural perturbations. Current drugs used in the management of the disease are associated with serious side effects. Therefore, compounds with ... -
MOLECULAR CHARACTERIZATION OF IMPROVED CASSAVA CULTIVARS AND COMMONLY GROWN NIGERIAN LANDRACES USING SIMPLE SEQUENCE REPEAT MARKERS
(2004-02)Cassava is a starchy staple food of tropical Africa whose yield is affected by several biotic stresses. Improved cassava cultivars that are resistant to biotic stresses were developed to boost cassava production. Also, ... -
INHIBITION OF HUMAN HAEMOGLOBIN GLYCOSYLATION BY FLAVONOIDS CONTAINING METHANOLIC EXTRACTS OF THE LEAF OF Cnestis ferruginea
(2002-10)Protein glycosylation by a sugar adduction, an oxidative process is exemplified by the glycosylation of haemoglobin A. The objective of this study, therefore, is to assess the influence of the leaf extracts of Cnestis ... -
EFFECTS OF QUASSIA AMARA AND QUASSIN ON EPIDIDYMAL FUNCTIONS AND HORMONAL PROFILES IN RATS AND THEIR OFFSPRINGS
(2014-04)Quassia amara is a medicinal plant with antimicrobial and bitter stomachic properties. This plant and its bioactive compound quassin, have been reported to decrease sperm count, sperm motility, male fertility index and ...
