Faculty of Basic Medical Sciences: Recent submissions
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THE RELATIONSHIP OF ENDOCRINE DISRUPTORS WITH PITUIARY GONADAL, THYROID HORMONES AND SOME RECEPTORS IN NIGERIAN WOMEN WITH BREAST CANCER
(2016-03)Endocrine Disruptors (EDs) such as lead, cadmium, arsenic, polychlorinated biphenyls (PCBs) and bisphenol-A (BPA) are associated with increased risk of Breast Cancer (BCa). Human epithelial receptor, oestrogen, progesterone ... -
EFFECTS OF ACUTE CHRONIC ADMINISTRATION OF ETHANOL EXTRACT OF Cola nitida SCHOTT AND ENDLICHER (KOLANUT) AND CAFFEINE ON GLUCOSE METABOLISM IN RATS
(2015-12)Cola nitida is known for its high caffeine content. Caffeine administration has been shown to cause glucose intolerance and insulin resistance. However, few studies on the effect of kolanut and decaffeinated kolanut on ... -
REVERSAL OF SODIUM ARSENITE-INDUCED DELAY IN GASTRIC ULCER HEALING IN RATS BY KOLAVIRON, VITAMIN E AND ZINC
(2017-06)Arsenic acid is a major contaminant of various water sources used for human consumption and industrial activities in most developing countries. It has been reported to cause degenerative inflammation and oxidative damage ... -
PROTECTIVE EFFECT OF Pterocarpus mildbraedii HARMS EXTRACT ON PROPANIL-INDUCED HEPATOTOXICITY AND ALTERATIONS IN APOPTOTIC RELATED PROTEINS IN WISTAR RATS
(2017-05)One of the probable causes of liver diseases is exposure to environmental chemicals. Agrochemicals containing propanil are known to induce hepatic toxicity. Pterocarpus mildbraedii leaf is used in traditional medicine to ... -
CHEMOPROTECTIVE ROLE OF 6-GINGEROL IN ULCERATIVE COLITIS AND COLORECTAL CANCER IN BALB/c MICE
(2017-11)Ulcerative colitis (UC) is an inflammatory disease of the colon that predisposes to colorectal cancer (CRC), the fourth leading cause of cancer death worldwide. Some drugs used in treatment of UC and CRC have adverse ... -
EVALUATION OF ANTPSYCHOTIC EFFECTS OF METHYL JASMONATE IN MICE
(2017-01)Psychosis is a chronic neurological disorder that impairs the quality of life of the patients and remains a major health challenge worldwide. Current drugs used to manage psychosis are expensive and only provide symptomatic ... -
EFFECTS OF VITAMIN C ON CARDIAC AUTONOMIC FUNCTION, OXIDATIVE STRESS AND DYSLIPIDAEMIA IN FRUCTOSE-ALLOXAN DIABETIC RATS
(2017-06)Cardiac Autonomic Neuropathy (CAN) is characterised by cardiac autonomic dysfunction and is the principal cause of mortality in type-2 diabetes. Oxidative stress has been implicated in the aetiology of CAN, thus antioxidants ... -
NEUROBEHAVIOURAL AND NEUROPROTECTIVE EFFECTS OF KOLAVIRON IN LABORATORY RODENTS
(2017-06)The high cost of orthodox medicines and their attendant side effects in some cases make the search for an effective and affordable alternative imperative. Kalaviron, a complex biflavanoid from Garcinia kola seeds, possesses ... -
EFFECTS OF MATERNAL SLEEP DEPRIVATION ON REPRODUCTIVE FUNCTIONS OF MALE OFFSPRINGS IN WISTRAR RATS
(2017-07)Maternal Sleep Deprivation (MSD) has been reported to alter sexual performance in offsprings of rats. There is paucity of information on the critical period during gestation at which MSD affects reproductive functions. ... -
REVERSAL OF SODIUM ARSENITE-INDUCED DELAY IN GASTRIC ULCER HEALING IN RATS BY KOLAVIRON, VITAMIN E AND ZINC
(2017-06)Arsenic acid is a major contaminant of various water sources used for human consumption and industrial activities in most developing countries. It has been reported to cause degenerative inflammation and oxidative damage ... -
THE ROLE OF THE GASTROINTESTINAL TRACT IN GLUCOSE HOMEOSTASIS
(1992-06)This study was designed to investigate the role of the gastrointestinal tract in glucose handling during hyperglycaemia induced by infusion of glucose, injection of glucagon or adrenaline and during insulin -induced ... -
EFFECTS OF Portulaca oleracea EXTRACTS ON HAEMATOLOGICAL, SERUM BIOCHEMICAL AND REPRODUCTIVE PARAMETERS IN ALBINO RATS
(2010-11)Portulaca oleracea is a herb used locally for foetal development in Edo State, Nigeria. Several studies have reported the gastrointestinal and neurological effects of the extracts, but there is a dearth of information on ... -
ERECTOGENIC AND SPERMIOLOGIC EFFECTS OF STEM BARK EXTRACTS OF Nauclea Latifolia (Smith) IN RABBITS
(2015-01)Erectile dysfunction is a sexual disorder to which both natural and synthetic remedies are being sought. Extract of Nauclea latifola (NL) has been used in folkloric medicine to ameliorate this sexual disorder; however there ... -
EVALUATION OF AUTOANTIBODIES AND HEPATITIS VIRAL MARKERS IN NIGERIANS WITH LIVER DISEASES
(2011-01)Liver disease is a major public health problem. Several diagnostic and aetiologic agents of liver diseases are known, but autoantibodies to liver antigens in Nigerians with liver diseases have not been extensively studied. ... -
MECHANISMS OF THE ANTI-GASTRIC ULCER ACTIVITY OF RISPERIDONE IN MALE RATS
(2015-02)Gastric ulcer and its treatment is a global problem, thus the search for a novel drug becomes a continuous one. Risperidone, though, anti-psychotic has been found to exhibit anti-ulcer activity, however, its mechanisms of ... -
EFFECTS OF STEM BARK EXTRACT OF Alstonia boonei ON Plasmodium berghei berghei-INDUCED MALARIA IN MICE AND ON MITOCHONDRIAL PERMEABILITY TRANSITION PORE
(2013-12)Mitochondrial Membrane Permeability Transition (MMPT) pore is a target for pharmacological intervention since the release of cytochrome c upon its opening is the point of no return for apoptosis. A number of antimalarial ... -
EFFECTS OF MATERNAL SLEEP DEPRIVATION ON REPRODUCTIVE FUNCTIONS OF MALE OFFSPRINGS IN WISTAR RATS
(2017-07)Maternal Sleep Deprivation (MSD) has been reported to alter sexual performance in offsprings of rats. There is paucity of information on the critical period during gestation at which MSD affects reproductive functions. ... -
EFFECTS OF METHANOL EXTRACT OF Artocarpus altilis (BREADFRUIT) ON ATHEROGENIC INDICES AND REDOX STATUS OF CELLULAR SYSTEM OF HYPERCHOLESTEROLEMIC RATS
(2014-09)Hypercholesterolemia is a dominant risk factor for the development of cardiovascular diseases and has become a growing problem globally. Pharmacological interventions for the treatment of hypercholesterolemia involve the ... -
THE ROLE OF OXIDATIVE STRESS IN BIOCHEMICAL, SEMINOLOGICAL AND HISTOLOGICAL CHANGES DURING ACUTE ADMINISTRATION OF ARTEMETHER
(2010)Artemether is an antimalarial drug which is effective in the treatment of multidrug resistant malaria but also induces oxidative stress in tissues. Limited information is available on role of oxidative stress in tissue ... -
EFFECT OF CO-ADMINISTRATION OF ACETAMINOPHEN AND METHIONINE ON MICRONUTRIENT METABOLISM
(2013-06)Generally, altered micro-nutrient levels affect the anti-oxidant defense mechanism and impact significantly on genomic stability. Acetaminophen induces tissue damage, which is prevented by methionine. However, the influence ...
