Variation in the sensitivity to normal human serum of clone-drived antigenic variants of trypanosoma (trypanozoon) brucei complex trypanosomes

Abstract

The present concept of T. rhodesiense sleeping sickness epidemiology rests, to some extent at least, upon the long-held belief that the infectivity for man of Trypanosoma (Trypanozoon rhodesiense and the non-infectivity for man of queei are constant and stable properties. Renewed interest has recently been taken in the effect of normal human serum on trypanosome population of distinct antigenic type, derive from clones prepared from T.rhodesiense and T. ibrucei samples syringe-passaged in white mice.