Microalbuminuria and serum creatinine in type 2 diabetes mellitus patients attending renal clinic at university teaching hospital in Lusaka,Zambia

Abstract

The study sought to investigate the presence of Micro-albuminuria (MA) in urine. MA urinary albumin excretion is in the range of 30 mg/24 hrs -300 mg/24 hrs. Consequently, urine albumin excretion has become a key therapeutic target in the management of patients with diabetes mellitus (DM). We aimed at describing the association between Micro-albuminuria, Serum Creatinine and fasting blood glucose in type 2 diabetes mellitus in patients attending Renal Clinic at University Teaching Hospital (UTH).This was an unmatched case control study involving 90 participants from UTH Renal Clinic. The cases included 45 type 2 diabetic patients who met the selection criteria and 45 non-diabetic controls. Blood and Spot urine samples were collected and analyzed for serum creatinine and micro-albuminuria respectively. We found a significant difference in the mean serum creatinine levels between the diabetics (95% CI= 4.231 - 4.438) and controls (95% CI= 3.943-4.163), p= 0.0003. The mean Micro-albuminuria levels between diabetics (95% CI= 3.405 – 3.737) and controls (95% CI = 2.967-3.266), also showed a significant difference, p=0.0001. Serum creatinine showed a weak positive correlation with fasting blood glucose, (r =0.2995 p =0.004) while Micro-albuminuria showed a strong positive correlation with fasting blood glucose, (r =0.3092, p =0.0030). In Zambian setting, both serum creatinine and Micro-albuminuria levels are significantly higher in type 2 diabetes patients compared to controls. Fasting blood glucose levels positively correlated with serum creatinine levels and Micro-albuminuria. Key words: Micro-albuminuria, Serum Creatinine, Diabetes Mellitus, Fasting blood glucose