Faculty of Basic Medical Sciences: Recent submissions
Now showing items 101-120 of 153
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DELAYED HEALING OF ACETIC ACID-INDUCED ULCERATION IN THE STOMACH OF LEAD-EXPOSED RATS
(2014-01)Reported cases of environmental lead exposure and its effects on the health of humans and livestock are on the increase globally. Lead affects many biological systems leading to death if it is beyond acceptable limits. ... -
AMELIORATIVE ROLE OF SELECTED MICRONUTRIENT SUPPLEMENTS ON OXIDATIVE STRESS AND WOUND HEALING IN DIABETIC RATS AND TYPE 2 DIABETICS
(2012-03)Oxidative Stress (OS) has been implicated in aetiology of Diabetes Mellitus (DM) and its complications including Diabetic Foot Ulcer (DFU). The role of antioxidant micronutrient supplementation on enzymatic and non-enzymatic ... -
CYTOKINES, REPRODUCTIVE HORMONES AND OXIDATIVE STRESS INDICES IN GENITAL CHLAMYDIA INFECTION IN NIGERIANS WITH TUBAL INFERTILITY
(2012-11)Tubal damage is the commonest cause of infertility in Nigerians and Genital Chlamydia Infection (GCI) is one of the major causes. Pathologic mechanisms involving hormonal, oxidative and cytokine responses have been suggested ... -
THE CONTRIBUTION OF ENDOCRINE DISRUPTING HEAVY METALS TO OESTRADIOL MODULATION AND SEMEN QUALITY IN NIGERIAN MEN
(2011-06)Declining male fertility is of global concern and has been linked to the effects of endocrine disruptors on the modulation of oestradiol. These disruptors are also recognised to be toxic to the testes. Selenium and zinc ... -
DETERMINANTS OF RESPONSES TO ANTIMALARIAL DRUGS IN CHILDREN WITH UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA
(2011-03)Drug resistance is a challenge to malaria control efforts and several factors including parasite genetics, host factors and pharmacokinetics may contribute to the selection of drug resistant Plasmodium falciparum. Understanding ... -
ANTIMALARIAL AND ANTITUBERCULAR ACTIVITIES OF CRUDE METHANOL EXTRACT AND FRACTIONS OF THE BULB OF CRINUM JAGUS ( Linn.)
(2015-02)Crinum jagus is a medicinal plant used traditionally to treat tuberculosis, malaria and other bacterial infections. However, there are limited documented scientific studies to substantiate the use of this plant. Due to ... -
PROTECTIVE EFFECTS OF METHANOL EXTRACT OF Allium cepa ON CYANIDE-INDUCED TOXICITY IN WISTAR RATS
(2015-04)Cyanide inhibits cellular cytochrome C oxidase, promotes reactive oxygen species production and causes organ damage. The possible ameliorative effects of Methanol Extract of the Bulb of Allium cepa (MEAC) on cyanide intake ... -
EFFECTS OF CHLOROQUINE, ARTHEMETER-LUMEFANTRINE AND ARTESUNATE ON EXPERIMENTAL COLITIS IN RATS
(2014-02)Ulcerative colitis is a chronic inflammatory bowel disease characterised by inflammation, ulceration and bleeding of the colonic mucosa. The etiology is still unknown. Studies have shown that some anti-malarial drugs ... -
COMPARATIVE METABOLISM OF LINAMARIN (2β-D- GLUCOPYRANOSYL OXY) -2METHYLPROPANE NITRILE) IN RATS AND MICE
(2013-07)Cyanide interferes, acutely, with cellular respiration by inhibiting cytsochrome oxidase activity. Living in the tropics increased vulnerability to cyanide mainly through ingestion of free Hydrocyanic Acid (HCN) derived ... -
METABOLISM OF LIPIDS IN KWASHIORKOR
(1969)A study of lipid metabolism in Nigeria kwashiorkor children has shown that the serum phospholipids, total cholesterol, cholesterol esters and total fatty acid levels were low when compared with the values for control ... -
STUDIES IN LIPOPROTEIN LIPASES (HEPATIC AND ENTRAHEPATIC) IN PROTEIN CALORIE MALNUTRITION
(1979-02)Protein-calorie malnutrition (PCM) is a common paediatric problem in Nigeria and the two main types, kwashiorkor and marasmus show differences in serum lipid profiles. The role of lipoprotein lipase (LPL.) in lipid ... -
THE EFFECTS OF PROTEIN-CALORIE MALNUTRITION AND CHLOROQUINE THERAPY ON THE CONJUGATION OF OESTRADIOL-178 BY THE RAT LIVER
(1976-08)The conjugation of 14e-oestradiol-l7 β by rat liver homogenates was studied using a modified version of Boo and Breuer’s method (1969). This consists of incubating the homogenates with cofactors at 37°C for four hours and ... -
A STUDY OF THE EFFECT OF INDUCED MALARIA (P.BERGHEI) ON THE TRANSKETOLAEE ACTIVITY AND RELATED BIOMEDICAL INDICES IN MICE AND RAT
(1984-07)Induced cerebral malaria (P. berghei) studied in mice and rats produced significant loss in the activity of the energy, transketolase which resulted in elevated thiamine pyrophosphate percentage effect (TPP%E) indicating ... -
EFFECT OF GAMMA IRRADIATION ON ASPERGILLUS FLAVUS AND SOME OF ITS TOXIC METABOLITES
(1976-09)Studies on the resistance of aflatoxin B1, B1 + B2, G1 and G1 + G2 against gamma irradiation in the dry state and when dissolved in chloroform or methanol were carried out by means of thin-layer chromatography, fluorescence ... -
STUDIES IN POSSIBLE BIOCHEMICAL FACTORS IN NIRIDAZONE (Anbilhar) INDUCED TOXICITY
(1983-05)Some biochemical interactions of various doses of Niridazole with tissue components have been studied. In-vivo and in-vitro studies with rats have shown that (14C) Niridazole (Anbilhar) binds covalently to tissue proteins ... -
BIOCHEMICAL STUDIES OF SOME PLANT EXTRACTS IN USE AS ANTI-MALARIALS IN WESTERN NIGERIA
(1975-09)In order to investigate the antimalarial property of some local medicinal plants namely Asardirachta indica, Morlnda lucida, Alstonia boonei, Enantia ohlorantha and some mixtures of plants used especially in the Western ... -
COMPARATIVE EFFECTS OF THE AFLATOXINS ON SOME ENERGY-LINKED FUNCTIONS OF RAT LIVER MITOCHONDRIA IN VITRO
(1975-09)Aflatoxins B1, B2, M1, G1 and G2 were isolated and purified. By chemical, spectrophotometric and polarographic techniques, the effects of these compounds on some energy-linked functions of rat liver mitochondria were ... -
INTERACTION OF PROSTAGLANDIN E2(PGE2) WITH NORADRENARINE AND ITS ANTAGONISTS IN THE ISOLATED MESSENTRIC ARTERY OF RAT
(1980-07)The effect of PG32, PGF2a- and PGI2, on vasoconstriction induced by different mechanisms was studied in the isolated rat mesenteric artery as described by McGregor (1965). Vasoconstriction was induced by mechanisms involving ... -
EFFECT OF TRADITIONAL FOOD PREPARATION TECHNIQUE ON THE NUTRITIVE VALUE OF THE FRUIT OF TRECULIA AFRICANA
(1979-09)A nutritional study was carried out with the fruit of the tree, Treculia Africana. This fruit is used as food in many parts of Africa. In this study, the whole fruit of the plant, Treculia Africana, the raw unprocessed ... -
THE NUTRIENT COMPOSITION OF SOME NIGERIAN LEAFY GREEN VEGETABLES AND PHYSIOLOGICAL AVAILABILITY OF THEIR IRON CONTENT
(1977-04)Ten leafy green vegetables, commonly incorporated into diets by peasants of the Cross River State of Nigeria, have been analyzed for their various nutrient contents. The vegetables were Abelmoschus esculentus, Corohorus ...
