Browsing Faculty of Basic Medical Sciences by Title
Now showing items 21-40 of 153
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CHARACTERIZATION OF NIGERIAN STRAINS OF NEWCASTLE DISEASE VIRUS
(1987-11-27)Natural outbreaks of Newcastle disease were investigated in different parts of Nigeria and samples for virus isolations were collected from vaccinated and unvaccinated commercial farms and indigenous chickens. Eleven NDV ... -
CHEMICAL AND BIOCHEMICAL STUDIES OF TOXIC FLUORESCENT SUBSTANCE PRODUCED BY ASPERGILLUS FLAVUS (LINK) WHEN CULTURED ON PALMSAP
(1969-09)Czapek medium, Czapek-Dox medium, glucose-ammonium nitrate medium and palmwine of different ages have been used in the culture of Aspergillus flavus (Link ex Fries). Of these growth media, unfermented palmwine (palmsap) ... -
CHEMICAL AND BIOCHEMICAL STUDIES ON LEAF PROTEINS
(1978-08)Six leafy green vegetables commonly incorporated into diets by the Ibos of Anambra and Imo States of Nigeria have been used in this study. The vegetables were: Telfairia ocoidentalis, Celosia ,argeltea 'green' Celosia ... -
CHEMOPROTECTIVE ROLE OF 6-GINGEROL IN ULCERATIVE COLITIS AND COLORECTAL CANCER IN BALB/c MICE
(2017-11)Ulcerative colitis (UC) is an inflammatory disease of the colon that predisposes to colorectal cancer (CRC), the fourth leading cause of cancer death worldwide. Some drugs used in treatment of UC and CRC have adverse ... -
CHEMOTHERAPEUTIC AND IMMUNOLOGICAL STUDIES ON STRAIN OF TRIPANOSOMA CONCOLENSE
(1968-12)(l) The adaptation of two strains of T.congolense from cattle to rats is described. One of them, the Ibadan strain, showed the phenomenon of polymorphism after being transmitted for four and a half years in rats. (2) The ... -
COBALT AND IRON CONSUMPTION IN MAN ( A COMPARATIVE STUDY OF TH E FACTORS REGULATING ABSORPTION IN SUBJECT WITH OR WITHOUT DISORDERS OF IRON METABOLISM
(1971)A direct correlation was found between the intestinal absorption of cobalt and iron over the range of values where iron absorption is normal or increased. This observation demonstrates that cobalt and iron share at least ... -
COMPARATIVE EFFECTS OF THE AFLATOXINS ON SOME ENERGY-LINKED FUNCTIONS OF RAT LIVER MITOCHONDRIA IN VITRO
(1975-09)Aflatoxins B1, B2, M1, G1 and G2 were isolated and purified. By chemical, spectrophotometric and polarographic techniques, the effects of these compounds on some energy-linked functions of rat liver mitochondria were ... -
COMPARATIVE METABOLISM OF LINAMARIN (2β-D- GLUCOPYRANOSYL OXY) -2METHYLPROPANE NITRILE) IN RATS AND MICE
(2013-07)Cyanide interferes, acutely, with cellular respiration by inhibiting cytsochrome oxidase activity. Living in the tropics increased vulnerability to cyanide mainly through ingestion of free Hydrocyanic Acid (HCN) derived ... -
A COMPARATIVE STUDY OF THE STRUCTURES OF THE RED CELL MEMBRANES AND THE CALCIUM-PUMPING ADENOSINE TRIPHOSPHATASE IN SOME MAMMALIAN SPECIES
(1984-05)Erythrocyte ghost membranes were isolated from blood samples obtained from five mammalian species, namely: (i) human (Homo sapiens), (ii) bovine (Bos taurus), (iii) porcine (Sus scrofa melitensis), (iv) ovine (Ovis aries ... -
THE CONTRIBUTION OF ENDOCRINE DISRUPTING HEAVY METALS TO OESTRADIOL MODULATION AND SEMEN QUALITY IN NIGERIAN MEN
(2011-06)Declining male fertility is of global concern and has been linked to the effects of endocrine disruptors on the modulation of oestradiol. These disruptors are also recognised to be toxic to the testes. Selenium and zinc ... -
CYTOKINES, REPRODUCTIVE HORMONES AND OXIDATIVE STRESS INDICES IN GENITAL CHLAMYDIA INFECTION IN NIGERIANS WITH TUBAL INFERTILITY
(2012-11)Tubal damage is the commonest cause of infertility in Nigerians and Genital Chlamydia Infection (GCI) is one of the major causes. Pathologic mechanisms involving hormonal, oxidative and cytokine responses have been suggested ... -
CYTOREMEDIATION OF SODIUM ARSENTIE-INDUCED TOXICITIES BY EXTRACT OF adansonia digitata LINN. IN CELL LINES AND WISTAR RATS
(2018-01)Arsenicals are proven human and animal environmental clastogens and carcinogens. Research has focused on ameliorating their toxicities using medicinal plants such as Adansonia digitata (AD). Although, there are available ... -
CYTOTOXICITY OF HEXAVALENT CHROMATE COMPOUNDS IN CH310T1/2 CELLS AND CYTOMODULATION BY SODIUM ARSENITE AND METHANOL EXTRACT OF Rauvolfia vomitora (Afzel) IN MICE
(2015-02)Exposure to certain hexavalent chromate compounds (HCC) causes lung and colon cancers. Their mechanisms of cytotoxicity are unclear, but believed to be affected by ascorbate and particle size. However, their role is not ... -
DELAYED HEALING OF ACETIC ACID-INDUCED ULCERATION IN THE STOMACH OF LEAD-EXPOSED RATS
(2014-01)Reported cases of environmental lead exposure and its effects on the health of humans and livestock are on the increase globally. Lead affects many biological systems leading to death if it is beyond acceptable limits. ... -
DETERMINANTS OF RESPONSES TO ANTIMALARIAL DRUGS IN CHILDREN WITH UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA
(2011-03)Drug resistance is a challenge to malaria control efforts and several factors including parasite genetics, host factors and pharmacokinetics may contribute to the selection of drug resistant Plasmodium falciparum. Understanding ... -
DISPOSITION AND ANTIMALARIAL ACTIVITIES OF THE DESETHYL METABOLITES OF CHLOROQUINE
(1985-05)A fluorimetric method for the selective determination of chloroquine (chq) from biological samples following dichloromethane extraction is described. It involves the reaction of the dichloromethane extracted primary and ... -
DISPOSITION OF AMODIAQUINE IN EXPERIMENTAL ANIMALS
(1988-12)The pharmacokinetics of amodiaquine have been examined in experimental animals (rats and rabbits) using an improved non-selective fluorimetric and more selective high performance liquid chromatographic (HPLC) methods with ... -
EFFECT OF CO-ADMINISTRATION OF ACETAMINOPHEN AND METHIONINE ON MICRONUTRIENT METABOLISM
(2013-06)Generally, altered micro-nutrient levels affect the anti-oxidant defense mechanism and impact significantly on genomic stability. Acetaminophen induces tissue damage, which is prevented by methionine. However, the influence ... -
THE EFFECT OF DIET AND AFLATOXIN INTAKE OF BLOOD-CLOTTING TIME AND SOME SERUM CONSTITUENTS IN NON-HUMAN PRIMATE
(1977-09)The effects of diet and aflatoxin intake on blood coagulation and serum lipid levels investigated in four different species of non-human primates namely, Carcopithecus aethiops Tantalus, Erythrocebus patas, Cercopithecus ... -
THE EFFECT OF DIET ON THE METABOLISM OF AFLATOXIN IN THE MAMMAL
(1968-04)The metabolic fate of aflatoxin is of interest in connection with studies related to the mode of action of hepatotoxins in the induction of liver tumors. The ability of the toxin to interact with sub-cellular particles and ...