Browsing Faculty of Basic Medical Sciences by Title
Now showing items 114-133 of 153
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ORUNGO ( UgMP 359) VIRUS: A HITHERTO UNDESCRIBED VIRUS, BIOCHEMICAL, BIOPHYSICAL AND EPIDEMIOLOGICAL STUDIES
(1976-07-14)Orungo virus, a hitherto undescribed virus, first isoated from a pool of Anopheles mosquitoes caught off human bait in Uganda was studied by biochemical, biophysical and sero- epidemiological methods. These studies were ... -
PHARMACOLOGY STUDIES ON PRAZOSIN, A NEW ANTIHYPERTENSIVE AGENT
(1980-01)The anti-hypertensive drug prazosin brings about a blockage of alpha adrenoceptors which is thought to be different from that caused by conventional alpha adrenoceptor blocking agents. Similarly unlike conventional alpha ... -
PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON SOME CONSTITUENTS OF VERNONIA AMYGDALINA
(1995-11)Some saponins and flavonoids occuring in the leaves of Vernonia amygdalina (Compositae) and the biological response they elicited were investigated. C18 fractionation of a 169 g methanolic extract of the leaves using 30-70% ... -
PRESENCE OF N-NITROSAMINES AND RELATED COMPOUNDS IN HUMAN AND ANIMAL FOODS
(1991-02)The nitrosamine, nitrate, ntirite and amine contents of some indigenous vegetables, soup condiments, cereals, food staples and forages of tropical interest were investigated. Also examined were the nitrosation of these ... -
PRODUCTION OF MONOCLONAL AND POLYCLONAL ANTIBODIES FOR THE DIAGNOSIS OF BANANA STREAK VIRUS, GENUS BADNAVIRUS
(2001-07)BSV was isolated and purified from infected leaves of IITA plantain hybrids (TMPx) by Methods A & B. Method A involved the use of sucrose cushion and caesium gradient during ultracentrifugation, while method B involved the ... -
PROSTAGLANDIN AND GONADOTROPIN STIMULATION OF TESTOSTERONE SECRETION IN THE RAT TESTIS
(1981-01)The response of the rat testis in vitro to gonadotropin and prostagladin El stimulation of testosterone secretion at different stages of rat development was studied. The technique employed involved the incubation of ... -
PROTECTIVE EFFECT OF Pterocarpus mildbraedii HARMS EXTRACT ON PROPANIL-INDUCED HEPATOTOXICITY AND ALTERATIONS IN APOPTOTIC RELATED PROTEINS IN WISTAR RATS
(2017-05)One of the probable causes of liver diseases is exposure to environmental chemicals. Agrochemicals containing propanil are known to induce hepatic toxicity. Pterocarpus mildbraedii leaf is used in traditional medicine to ... -
PROTECTIVE EFFECTS OF KOLAVIRON AND QUERCETIN ON ATRAZINE-INDUCED NEURONAL AND TESTICULAR DAMAGE IN CELL LINES AND RATS
(2012-10)Neurodegenerative diseases and decline in male fertility are reported to be associated with exposure to environmental chemicals. Many agrochemicals including atrazine are known to induce reproductive and neuronal toxicity. ... -
PROTECTIVE EFFECTS OF METHANOL EXTRACT OF Allium cepa ON CYANIDE-INDUCED TOXICITY IN WISTAR RATS
(2015-04)Cyanide inhibits cellular cytochrome C oxidase, promotes reactive oxygen species production and causes organ damage. The possible ameliorative effects of Methanol Extract of the Bulb of Allium cepa (MEAC) on cyanide intake ... -
PROTECTIVE EFFECTS OF METHANOL EXTRACT OF Chasmanthera dependens HOCHST STEMON ACIDIFIED ETHANOL-AND INDOMETHACIN-INDUCED GASTRIC ULCER AND APOPTOSIS IN MALE WISTAR RATS
(2015)Gastric ulceration is a common clinical problem which may results from incessant use of drugs. Chasmanthera dependens possesses analgesic effects in experimental rats and anecdotal report exit on its gastric ulcerogenic ... -
PROTECTIVE EFFECTS OF QUERCETIN AND RUTIN ON SULFASALAZINE-INDUCED TESTICULAR TOXICITY AND APOPTOSIS IN MALE WISTAR RATS
(2015-08)Sulfasalazine is used as a therapy for inflammatory bowel diseases. High doses may be associated with male infertility; reversible only on drug withdrawal. Sulfasalazine metabolism generates oxidative stress as a mechanism ... -
PROTECTIVE ROLE OF PROTOCATECHUIC ACID IN NEVIRAPINE-INDUCED HEPATOTOXICITY AND APOPTOSIS IN MALE WISTER RATS
(2015-08)Nevirapine is a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) used in HIV-I treatment. Although efficacious, it produces toxic responses such as hepatotoxicity which is characterised by generation of free radicals. ... -
THE RELATIONSHIP OF ENDOCRINE DISRUPTORS WITH PITUIARY GONADAL, THYROID HORMONES AND SOME RECEPTORS IN NIGERIAN WOMEN WITH BREAST CANCER
(2016-03)Endocrine Disruptors (EDs) such as lead, cadmium, arsenic, polychlorinated biphenyls (PCBs) and bisphenol-A (BPA) are associated with increased risk of Breast Cancer (BCa). Human epithelial receptor, oestrogen, progesterone ... -
REVERSAL OF SODIUM ARSENITE-INDUCED DELAY IN GASTRIC ULCER HEALING IN RATS BY KOLAVIRON, VITAMIN E AND ZINC
(2017-06)Arsenic acid is a major contaminant of various water sources used for human consumption and industrial activities in most developing countries. It has been reported to cause degenerative inflammation and oxidative damage ... -
REVERSAL OF SODIUM ARSENITE-INDUCED DELAY IN GASTRIC ULCER HEALING IN RATS BY KOLAVIRON, VITAMIN E AND ZINC
(2017-06)Arsenic acid is a major contaminant of various water sources used for human consumption and industrial activities in most developing countries. It has been reported to cause degenerative inflammation and oxidative damage ... -
RIFT VALLEY FEVER VIRUS IN NIGERIA: COMPARATIVE EXPERIMENTAL INFECTIONS OF THREE BREEDS OF INDIGENOUE SHEEP AND SERO-SURVEY OF HUMAN AND ANIMAL POPULATIONS
(1990-09)Electron microscopic examination by negative staining and antigen controlled immunodiagnosis techniques on the Zinga virus used for this study showed that it is a strain of Rift Valley fever (RVF) virus. This is based on ... -
RISK FACTORS AND EFFECTS OF ANTIMALARIAL DRUGS ON PLASMODIUM FALCIPARUM GAMETOCYTAEMIA IN NIGERIAN CHILDREN
(2007-07)Gametocytes are the sexual forms of Plasmodium species that are essential for the transmission of malaria. However, there is little information on the factors that influence their generation or carriage, a measure of ... -
THE ROLE OF 5-HYDROXYTRYPTAMINE IN THE PATHOGENESIS OF ENDONYOCARDIAL FIBROSIS
(1968-06)ENDONYOCARDIAL FIBROSIS (E.M.F) is a common heart disease in certain areas of Africa. Much knowledge has accumulated in recent years about the pathology and clinical features of this disease; but at present, its pathogenesis ... -
THE ROLE OF KUPFFER CELLS IN ETHANOL AND AFLATOXIN B₁-INDUCED p53 GENE MUTATION IN HEPATOCARCINOGENESIS
(2009-06)Kupffer cells (KC) play an important role in hepatic homeostasis, and in acute and chronic response of the liver to endotoxins. The KC also mediate the release of cykokines and reactive oxygen species (ROS) involved in ... -
THE ROLE OF OXIDATIVE STRESS IN BIOCHEMICAL, SEMINOLOGICAL AND HISTOLOGICAL CHANGES DURING ACUTE ADMINISTRATION OF ARTEMETHER
(2010)Artemether is an antimalarial drug which is effective in the treatment of multidrug resistant malaria but also induces oxidative stress in tissues. Limited information is available on role of oxidative stress in tissue ...
