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dc.contributor.authorSu, RC
dc.contributor.authorSivro, A
dc.contributor.authorKimani, J
dc.contributor.authorJaoko Walter G.
dc.contributor.authorPlummer, FA
dc.contributor.authorBall, TB
dc.date.accessioned2019-09-04T13:10:36Z
dc.date.available2019-09-04T13:10:36Z
dc.date.issued2011-03
dc.identifierwww.ncbi.nlm.nih.gov/whalecom0/pubmed/21200019
dc.identifierhttp://hdl.handle.net/11295/32534
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062355/
dc.identifier.citationBlood. 2011 Mar 3;117(9):2649-57. doi: 10.1182/blood-2010-10-312462. Epub 2011 Jan 3en
dc.identifier.urihttps://library.adhl.africa/handle/123456789/7441
dc.description.abstractNot all individuals exposed to HIV become infected. Understanding why these HIV-exposed seronegative individuals remain uninfected will help inform the development of preventative measures against HIV infection. Interferon regulatory factor-1 (IRF1) plays a critical role both in host antiviral immunity and in HIV-1 replication. This study examined IRF1 expression regulation in the ex vivo peripheral blood mononuclear cells of HIV-exposed seronegative commercial sex workers who can be epidemiologically defined as relatively resistant to HIV infection (HIV-R), versus HIV-uninfected, susceptible controls (HIV-S). Whereas HIV-susceptible individuals demonstrated a biphasic, prolonged increase in IRF1 expression after interferon-γ stimulation, HIV-R individuals demonstrated a robust, but transient response. We also found that the IRF1 promoter in HIV-R was primed by increased basal histone deacetylase-2 binding, independently of transcription regulators, STAT1 and nuclear factor-κB/p65, implicating an epigenetic silencing mechanism. Interestingly, the transitory IRF1 response in HIV-R was sufficient in comparable regulation of interleukin-12 and interleukin-4 expression compared with the HIV-susceptible controls. This is the first study characterizing IRF1 responsiveness in individuals who demonstrate altered susceptibility to HIV infection. These data suggest that transitory IRF1 responsiveness in HIV-R may be one of the key contributors to the altered susceptibility to HIV infection during the early stages of primary HIV infectionen
dc.language.isoenen
dc.publisherUniversity of Nairobien
dc.titleEpigenetic Control Of Irf1 Responses In HIV-exposed Seronegative Versus HIV-susceptible Individuals.en
dc.typeArticleen


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