Assessment od Adiponectin and Endothelial Nitric Oxide Synthase levels in Black Zambian patients with Hypertension at the University Teaching Hospital, Lusaka

Abstract

Context - A number of biomarkers are implicated in the pathophysiology of hypertension. Low adiponectin levels have been associated with hypertension and this might be due to its effects on endothelial nitric oxide synthase levels. Aims - In this study we aimed to assess plasma adiponectin and endothelial nitric oxide synthase in patients with hypertension.Methods and Results - An analytical cross-sectional study was undertaken in black Zambians. Plasma adiponectin and endothelial nitric oxide synthase levels were assessed in hypertensive and non-hypertensive participants using ELISA. Our results showed that there was no difference in adiponectin levels between hypertensive and non-hypertensive participants (p=0.291). Our results showed that there was no difference in eNOS levels between hypertensive and non-hypertensive participants (p=0.197). Plasma adiponectin showed no correlation with eNOS in hypertension (r=0.036, p=0.825). Conclusion - The study showed that there was no difference in mean adiponectin concentration and mean eNOS concentration between hypertensive patients and non-hypertensive participants. There was no relationship between adiponectin and eNOS levels on their influence on hypertension.