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dc.contributor.authorALEGBE, R.A.
dc.date.accessioned2018-09-17T14:26:21Z
dc.date.accessioned2019-10-04T10:01:27Z
dc.date.available2018-09-17T14:26:21Z
dc.date.available2019-10-04T10:01:27Z
dc.date.issued1977-02
dc.identifier.urihttps://library.adhl.africa/handle/123456789/12382
dc.descriptionA THESIS IN THE DEPARTMENT OF PHYSIOLOGY OF THE COLLEGE OF MEDICINE IN PARTIAL FULFILLMENT OF THE DEGREE OF DOCTOR OF PHILOSOPHY OF THE UNIVERSITY OF IBADAN, IBADAN, NIGERIA.en_US
dc.description.abstractUsing as experimental models, chronic and acute peptic ulcerations produced in rats by means of prolonged starvation and indomethacin, the role of (i) the hypothalamo-neurohypophyseal-neuro secretory system (H.N.N.S_) and (ii) the hormone, gastrin were studied in the pathogenesis of peptic ulceration. In the case of acute indomethacin-induced peptic ulceration, the effects of anti-cholinergic drugs on the ulcers produced were also studied. 2. Based on the well observed ameliorating effect of pregnancy on peptic ulceration in human-beings, the presence of ulcerogenic as well as ulcer-ameliorating substances, such as gastrin and the prostaglandins were looked for and characterised in extracts of human placenta. 3. It was observed that (i) both starvation and indomethacin-induced peptic ulceration were associated with a low neurohypophyseal neuro-secretory material (N.S.M.), (ii.) starvation-induced peptic ulceration was not associated with a significant change in antral gastrin content, (iii) anticholinergic drugs significantly prevented indomethacin-induced ulcers in rats, (iv) human placenta had no detectable gastrin-like activity but contained significant amounts of PGE2 and PGF2,and (v) perfused stomach preparations from both the pregnant and oestrogen-pretreated rats caused significant inactivation of exogenous PGE2. The significance of the above findings are discussed in relation to the pathogenesis of peptic ulceration.en_US
dc.language.isoenen_US
dc.subjectPEPTIC ULCERATIONen_US
dc.subjectNEURO-HUMORAL FACTORSen_US
dc.subjectEXPERIMENTAL STUDIESen_US
dc.titleEXPERIMENTAL STUDIES ON THE ROLE OF NEURO-HUMORAL FACTORS IN PEPTIC ULCERATIONen_US
dc.typeThesisen_US


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