| dc.description.abstract | Using as experimental models, chronic and acute peptic ulcerations produced in rats by means of prolonged starvation and indomethacin, the role of (i) the hypothalamo-neurohypophyseal-neuro secretory system (H.N.N.S_) and (ii) the hormone, gastrin were studied in the pathogenesis of peptic ulceration. In the case of acute indomethacin-induced peptic ulceration, the effects of anti-cholinergic drugs on the ulcers produced were also studied.
2. Based on the well observed ameliorating effect of pregnancy on peptic ulceration in human-beings, the presence of ulcerogenic as well as ulcer-ameliorating substances, such as gastrin and the prostaglandins were looked for and characterised in extracts of human placenta.
3. It was observed that (i) both starvation and indomethacin-induced peptic ulceration were associated with a low neurohypophyseal neuro-secretory material (N.S.M.), (ii.) starvation-induced peptic ulceration was not associated with a significant change in antral gastrin content, (iii) anticholinergic drugs significantly prevented indomethacin-induced ulcers in rats, (iv) human placenta had no detectable gastrin-like activity but contained significant amounts of PGE2 and PGF2,and (v) perfused stomach preparations from both the pregnant and oestrogen-pretreated rats caused significant inactivation of exogenous PGE2.
The significance of the above findings are discussed in relation to the pathogenesis of peptic ulceration. | en_US |
