Browsing Faculty of Basic Medical Sciences by Title
Now showing items 88-107 of 153
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INFLUENCE OF FREE RADICAL -MEDIATED MEMBRANE DAMAGE ON ERYTHROCYTE Ca²⁺-HOMEOSTASIS IN CERTAIN PATHOLOGICAL STATES
(1990-11)The possible nature of toxic oxygen from radical species generated in vivo under pathological conditions as well as the relationship between oxygen free radicals and/or lipid peroxidation and the abnormal regulation of ... -
INHIBITION OF HUMAN HAEMOGLOBIN GLYCOSYLATION BY FLAVONOIDS CONTAINING METHANOLIC EXTRACTS OF THE LEAF OF Cnestis ferruginea
(2002-10)Protein glycosylation by a sugar adduction, an oxidative process is exemplified by the glycosylation of haemoglobin A. The objective of this study, therefore, is to assess the influence of the leaf extracts of Cnestis ... -
INSULIN SECRETION AND SENSITIVITY IN FIRST-DEGREE RELATIVES OF NIGERIAN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM)
(1992-02)The blood insulin and glucose concentrations were analysed before and during frequently sampled intravenous glucose tolerance tests (FSIGT) In 2 groups of Nigerian subjects: (1 ) Control group (n=18), without a positive ... -
INSULIN SECRETION IN NON-OBESE NIGERIANS (effect of glucose, sulphonylureas and weight reduction
(1974-07)Protein calorie malnutrition in man and experimental animals produces striking changes in the pancreas; and clinically, protein deficiency has been shown to diminish exocrine pancreatic secretions in addition to the ... -
INTERACTION OF PROSTAGLANDIN E2(PGE2) WITH NORADRENARINE AND ITS ANTAGONISTS IN THE ISOLATED MESSENTRIC ARTERY OF RAT
(1980-07)The effect of PG32, PGF2a- and PGI2, on vasoconstriction induced by different mechanisms was studied in the isolated rat mesenteric artery as described by McGregor (1965). Vasoconstriction was induced by mechanisms involving ... -
INTESTINAL HAEMODYNAMICS AND GLUCOSE UPTAKE FOLLOWING HEXOSES ADMINISTRATION IN DOGS
(2012-04)An increase in blood glucose levels has been reported to induce a rise in Intestinal Glucose Uptake (IGU) through reduction in Intestinal Vascular Resistance (IVR) and increase in Intestinal Blood Flow (IBF). However, ... -
THE INTRINSIC ANATOMICAL ORGANIZATION OF THE CUNEO-GRACILE NUCLEI COMPLEX OF THE RAT
(1977-02-23)The studies making up the thesis were aimed towards elucidating the intrinsic structural organization of the cuneo-gracile nuclei complex. The rat was the experimental animal of choice but limited data were collected from ... -
AN INVESTIGATION OF MECHANISM OF AMPICOGULANT ACTION OF AFLATOXIN IN SOME ANIMAL SPECIES
(1970-06)It has been reported that aflatoxin B₁ isolated from foodstuff contaminated with a toxin strain of Aspergillus Flavus produces in rats a lesion similar to the “sweet clover disease”. Biochemical, Kinetic and microscopic ... -
INVESTIGATIONS INTO CHANGES IN PLATELET FUNCTION IN EXPERIMENTAL MALARIA
(1985-08)In this thesis the problem of haemostatic disorders with particular reference to platelet dysfunction in experimental malaria models has been examined. In the Swiss albino mouse model infected with Plasmodium berghei (P. ... -
THE ISOLATION AND CHARACTERIZATION OF PORCINE ERYTHROCYTE Ca2+ - ADENOCINE TRIPHOSPHATASE
(1985-10)The Ca2+- pumping adenosine triphosphatase, Ca2+-ATPase, (ATP phosphohydrolase, EC 3.6.1.3), was purified from porcine erythrocyte membranes by calmodulin affinity chromatography in the presence of phosphatidylcholine and ... -
LANDFILL LEACHATE-INDUCED OXIDATIVE DAMAGE IN RAT AND AFRICAN CATFISH
(2014-06)Landfill leachate poses potential health hazards for man and his environment. Leachates can generate free radicals in exposed tissues. Free radicals may cause DNA damage and oxidative stress associated with many disease ... -
MAGNESIUM METABOLISM IN DIABETES MELLITUS AND THE EFFECTS OF MAGNESIUM ADMINISTRATION ON PLASMA GLUCOSE AND INSULIN LEVELS
(1995-09)Magnesium plays an important role in human metabolic activities. Its role in glucose metabolism is well established. However, there are still some conflicting views on the altered magnesium homeostasis in diabetic states ... -
MALARIA PARASITAEMIA AND HUMORAL IMMUNE RESPONSES TO SOME DEFINED PLASMODIUM FALCIPARUM ANTIGENS IN NEWBORNS, INFANTS AND ADULT NIGERIANS
(1994-08)A cohort of mothers and their newborns at Igbo-Ora, Oyo state was studied longitudinally for 12 months to determine the incidence of malaria parasitaemia, episodes of clinical malaria and their humoral immune response to ... -
MECHANISM OF ANTI-DIABETIC ACTIVITIES OF Musa sapientum LEAF EXTRACT IN RATS TREATED WITH ALLOXAN
(2014)Diabetes mellitus results from necrosis of pancreatic β-cell and insulin resistance at the cellular level. Musa sapientum has been shown to possess anti-diabetic properties. However, the mechanism of its action is unknown. ... -
MECHANISM OF ANTI-GASTRIC ULCER EFFECT OF BETULINIC ACID IN MALE ALBINO RATS
(2011-03)Betulinic acid (BA) is a lupane-type triterpene that has been identified and isolated from different plant species used in ethnomedicine worldwide. It is known to possess anti-ulcer, anti-tumor and anti-microbial properties. ... -
MECHANISMS OF THE ANTI-GASTRIC ULCER ACTIVITY OF RISPERIDONE IN MALE RATS
(2015-02)Gastric ulcer and its treatment is a global problem, thus the search for a novel drug becomes a continuous one. Risperidone, though, anti-psychotic has been found to exhibit anti-ulcer activity, however, its mechanisms of ... -
METABOLISM OF LIPIDS IN KWASHIORKOR
(1969)A study of lipid metabolism in Nigeria kwashiorkor children has shown that the serum phospholipids, total cholesterol, cholesterol esters and total fatty acid levels were low when compared with the values for control ... -
MODULATING EFFECT OF POLYCLONAL ANTIBODIES AGAINST AFLATOXIN B₁ MACROMOLECULAR COMPLEXES ON AFLATOXIN INDUCED HEPATOCARCINOGENESIS
(1990-11)Polyclonal immunoglobulin G antibodies were raised in adult male albino rabbits against aflatoxin B₁-bovine serum albumin, aflatoxin B₁-histone H₁ and aflatoxin B₁-microsomal proteins complexes after a single intradermal ... -
THE MODULATION OF RAT LIVER MICROSOMAL CALCIUM ION-PUMPING ATPase BY DICOPHANE AND LOW PROTEIN INTAKE
(1992-05)The effect of the liver tumour promoter, dicophane, with those of low protein intake (LPI) in the functional expression of rat liver microsomal Ca²⁺-ATPase were compared. The effects of dicophane and LPI on the activity ... -
MOLECULAR CHARACTERIZATION OF IMPROVED CASSAVA CULTIVARS AND COMMONLY GROWN NIGERIAN LANDRACES USING SIMPLE SEQUENCE REPEAT MARKERS
(2004-02)Cassava is a starchy staple food of tropical Africa whose yield is affected by several biotic stresses. Improved cassava cultivars that are resistant to biotic stresses were developed to boost cassava production. Also, ...