Browsing Faculty of Basic Medical Sciences by Title
Now showing items 131-150 of 153
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THE ROLE OF 5-HYDROXYTRYPTAMINE IN THE PATHOGENESIS OF ENDONYOCARDIAL FIBROSIS
(1968-06)ENDONYOCARDIAL FIBROSIS (E.M.F) is a common heart disease in certain areas of Africa. Much knowledge has accumulated in recent years about the pathology and clinical features of this disease; but at present, its pathogenesis ... -
THE ROLE OF KUPFFER CELLS IN ETHANOL AND AFLATOXIN B₁-INDUCED p53 GENE MUTATION IN HEPATOCARCINOGENESIS
(2009-06)Kupffer cells (KC) play an important role in hepatic homeostasis, and in acute and chronic response of the liver to endotoxins. The KC also mediate the release of cykokines and reactive oxygen species (ROS) involved in ... -
THE ROLE OF OXIDATIVE STRESS IN BIOCHEMICAL, SEMINOLOGICAL AND HISTOLOGICAL CHANGES DURING ACUTE ADMINISTRATION OF ARTEMETHER
(2010)Artemether is an antimalarial drug which is effective in the treatment of multidrug resistant malaria but also induces oxidative stress in tissues. Limited information is available on role of oxidative stress in tissue ... -
THE ROLE OF RODENT AND HUMAN FACTORS IN THE PREVALENCE OF ANTIBODY TO LASSA VIRUS IN NIGERIA AND SIERRA LEONE
(1996-03)Studies were conducted on distribution of Lassa fever (LF), a viral haemorrhagic disease in humans, in Nigeria and Sierra Leone and presence of Lassa virus (LV) in rodents as it relates to human infection, using the Enzyme ... -
THE ROLE OF THE GASTROINTESTINAL TRACT IN GLUCOSE HOMEOSTASIS
(1992-06)This study was designed to investigate the role of the gastrointestinal tract in glucose handling during hyperglycaemia induced by infusion of glucose, injection of glucagon or adrenaline and during insulin -induced ... -
SELECTED GENETIC RED-CELL MARKERS AND THE EPIDEMIOLOGY OF CHLOROQUINE-ASSOCIATED PRURITUS IN NIGERIA
(1994-02)Anecdotal reports suggest that there may be a familial component to Chloroquine-associated pruritus (CAP). To test this hypothesis, the epidemiology of CAP was studied with respect to hemoglobin S (HbS) and glucose-6-phosphate ... -
SOME CHARACTERISTICS OF Bartonella henselae AN OPPORTUNISTIC PATHOGEN IN ACQUIRED IMMUNE DEFICIENCY SYNDROME
(1997-12)Cat-scratch disease (CSD) is an infectious disease, implicated as an opportunistic infection in human immunodeficiency virus (HIV) patients. So far, Bartonella henselae (Rochalimaea henselae), remains the most acceptable ... -
SOME IMMUNOLOGICAL PARAMETERS AS INDICES OF AGING IN NIGERIANS
(1994-02)This study involved 541 participants. It assessed the state of body defence mechanisms during ageing in 217 healthy Nigerians aged 6-95 years. A different group of 274 healthy subjects of ages 6 to 60 years were studied ... -
SOME IMMUNOLOGICAL REACTIONS OF TRIPANOSONA GAMBIESSE ISOLATES
(1971-02)Serological characteristics and the protective effect of humeral antibodies (serum) were examined in rabbits (a) infected with Trypanosoma gambiense, (b) immunized with killed Trypanosoma gambiense, (c) immunized with ... -
SPERM ANTIBODY AS FACTOR OF INFERTILITY IN NIGERIAN MALES
(1999-04)Sperm antibodies (SA) have been observed as a cause of infertility. The production of the SA have in some circumstances been attributed to chronic infection of the genital tract. In Nigeria, sexually transmitted diseases ... -
STUDIES IN LIPOPROTEIN LIPASES (HEPATIC AND ENTRAHEPATIC) IN PROTEIN CALORIE MALNUTRITION
(1979-02)Protein-calorie malnutrition (PCM) is a common paediatric problem in Nigeria and the two main types, kwashiorkor and marasmus show differences in serum lipid profiles. The role of lipoprotein lipase (LPL.) in lipid ... -
STUDIES IN POSSIBLE BIOCHEMICAL FACTORS IN NIRIDAZONE (Anbilhar) INDUCED TOXICITY
(1983-05)Some biochemical interactions of various doses of Niridazole with tissue components have been studied. In-vivo and in-vitro studies with rats have shown that (14C) Niridazole (Anbilhar) binds covalently to tissue proteins ... -
STUDIES OF GESTATIONAL TRAPHOBLASTIC DISEASES IN IBADAN, NIGERIA
(1975-06)Gestational Trophallactic Diseases (MTD) embrace two main lesions of which is subdivided into two-hydatidiform mole, non-invasive and invasive (chorioadenoma destruens) and choriocarcinoma. These pregnancy-associated disease ... -
STUDIES OF ZINC AND ALKALINE PHOSPHATE ISOENZYMES IN NORMAL AND TOXAEMIC PREGNANCIES IN NIGERIANS
(1982-03)ABSTRACT There is at present no information on the metabolism of zinc It during pregnancy in Nigerians. A study of zinc and a zinc melalloenzyme was therefore considered worthwhile in normal and toxaemic pregnant Nigerian ... -
STUDIES ON CADMIUM TOXICITY IN RAT TISSUES
(1981-06)The presence of toxic levels of cadmium in the ecosystem has been increasing due to more and more industrial and agricultural use. Though several reports have appeared on renal damage, testicular necrosis and hepatotoxicity, ... -
STUDIES ON TEMPERATURE DISTRIBUTION AND HEAT PRODUCTION IN THE "CORE AREA" OF THE DOG
(1968-06)Temperature distribution within the "oore area" of fasting mongrel dogs was studied with thermocouples or "applicators" (the hot junctions of thermocouples - manufactured by ELLAB Ltd. Copenhagen). The highest intra-abdominal ... -
STUDIES ON THE BURKITT AND LYMPHORETICULAR TUMOURS IN NIGERIA
(1966-12)Burkitt’s tumour exemplifies the popular belief that lympho-reticular tumours are relatively more common in African than elsewhere. At the time the present studies were contemplated, its exact histogenesis was controversial, ... -
STUDIES ON THE PROBABLE EFFECT OF PROSTAGLANDINS ON CHOLINERGIC TRANSMISSION IN ISOLATED GUINEA-PIG ILEUM.
(1981-05)The effect of indomethacin, ketoprofen and sodium meclofenamate on contractions evoked by different stimuli in the guinea-pig ileum were investigated in Tyrode solution and in Krebs solution. The whole ileum preparation ... -
A STUDY OF THE EFFECT OF INDUCED MALARIA (P.BERGHEI) ON THE TRANSKETOLAEE ACTIVITY AND RELATED BIOMEDICAL INDICES IN MICE AND RAT
(1984-07)Induced cerebral malaria (P. berghei) studied in mice and rats produced significant loss in the activity of the energy, transketolase which resulted in elevated thiamine pyrophosphate percentage effect (TPP%E) indicating ... -
A STUDY OF THE EFFECT OF THE AFLATOXINS ON BLOOD CLOTTING
(1967-06)The structural configurations of the synthetic coumarins have been shown to be of major importance in their action on blood clotting. In view of the similarities in the structures of the synthetic coumarins and the aflatoxins, ...