Browsing Faculty of Basic Medical Sciences by Title
Now showing items 119-138 of 153
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PROSTAGLANDIN AND GONADOTROPIN STIMULATION OF TESTOSTERONE SECRETION IN THE RAT TESTIS
(1981-01)The response of the rat testis in vitro to gonadotropin and prostagladin El stimulation of testosterone secretion at different stages of rat development was studied. The technique employed involved the incubation of ... -
PROTECTIVE EFFECT OF Pterocarpus mildbraedii HARMS EXTRACT ON PROPANIL-INDUCED HEPATOTOXICITY AND ALTERATIONS IN APOPTOTIC RELATED PROTEINS IN WISTAR RATS
(2017-05)One of the probable causes of liver diseases is exposure to environmental chemicals. Agrochemicals containing propanil are known to induce hepatic toxicity. Pterocarpus mildbraedii leaf is used in traditional medicine to ... -
PROTECTIVE EFFECTS OF KOLAVIRON AND QUERCETIN ON ATRAZINE-INDUCED NEURONAL AND TESTICULAR DAMAGE IN CELL LINES AND RATS
(2012-10)Neurodegenerative diseases and decline in male fertility are reported to be associated with exposure to environmental chemicals. Many agrochemicals including atrazine are known to induce reproductive and neuronal toxicity. ... -
PROTECTIVE EFFECTS OF METHANOL EXTRACT OF Allium cepa ON CYANIDE-INDUCED TOXICITY IN WISTAR RATS
(2015-04)Cyanide inhibits cellular cytochrome C oxidase, promotes reactive oxygen species production and causes organ damage. The possible ameliorative effects of Methanol Extract of the Bulb of Allium cepa (MEAC) on cyanide intake ... -
PROTECTIVE EFFECTS OF METHANOL EXTRACT OF Chasmanthera dependens HOCHST STEMON ACIDIFIED ETHANOL-AND INDOMETHACIN-INDUCED GASTRIC ULCER AND APOPTOSIS IN MALE WISTAR RATS
(2015)Gastric ulceration is a common clinical problem which may results from incessant use of drugs. Chasmanthera dependens possesses analgesic effects in experimental rats and anecdotal report exit on its gastric ulcerogenic ... -
PROTECTIVE EFFECTS OF QUERCETIN AND RUTIN ON SULFASALAZINE-INDUCED TESTICULAR TOXICITY AND APOPTOSIS IN MALE WISTAR RATS
(2015-08)Sulfasalazine is used as a therapy for inflammatory bowel diseases. High doses may be associated with male infertility; reversible only on drug withdrawal. Sulfasalazine metabolism generates oxidative stress as a mechanism ... -
PROTECTIVE ROLE OF PROTOCATECHUIC ACID IN NEVIRAPINE-INDUCED HEPATOTOXICITY AND APOPTOSIS IN MALE WISTER RATS
(2015-08)Nevirapine is a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) used in HIV-I treatment. Although efficacious, it produces toxic responses such as hepatotoxicity which is characterised by generation of free radicals. ... -
THE RELATIONSHIP OF ENDOCRINE DISRUPTORS WITH PITUIARY GONADAL, THYROID HORMONES AND SOME RECEPTORS IN NIGERIAN WOMEN WITH BREAST CANCER
(2016-03)Endocrine Disruptors (EDs) such as lead, cadmium, arsenic, polychlorinated biphenyls (PCBs) and bisphenol-A (BPA) are associated with increased risk of Breast Cancer (BCa). Human epithelial receptor, oestrogen, progesterone ... -
REVERSAL OF SODIUM ARSENITE-INDUCED DELAY IN GASTRIC ULCER HEALING IN RATS BY KOLAVIRON, VITAMIN E AND ZINC
(2017-06)Arsenic acid is a major contaminant of various water sources used for human consumption and industrial activities in most developing countries. It has been reported to cause degenerative inflammation and oxidative damage ... -
REVERSAL OF SODIUM ARSENITE-INDUCED DELAY IN GASTRIC ULCER HEALING IN RATS BY KOLAVIRON, VITAMIN E AND ZINC
(2017-06)Arsenic acid is a major contaminant of various water sources used for human consumption and industrial activities in most developing countries. It has been reported to cause degenerative inflammation and oxidative damage ... -
RIFT VALLEY FEVER VIRUS IN NIGERIA: COMPARATIVE EXPERIMENTAL INFECTIONS OF THREE BREEDS OF INDIGENOUE SHEEP AND SERO-SURVEY OF HUMAN AND ANIMAL POPULATIONS
(1990-09)Electron microscopic examination by negative staining and antigen controlled immunodiagnosis techniques on the Zinga virus used for this study showed that it is a strain of Rift Valley fever (RVF) virus. This is based on ... -
RISK FACTORS AND EFFECTS OF ANTIMALARIAL DRUGS ON PLASMODIUM FALCIPARUM GAMETOCYTAEMIA IN NIGERIAN CHILDREN
(2007-07)Gametocytes are the sexual forms of Plasmodium species that are essential for the transmission of malaria. However, there is little information on the factors that influence their generation or carriage, a measure of ... -
THE ROLE OF 5-HYDROXYTRYPTAMINE IN THE PATHOGENESIS OF ENDONYOCARDIAL FIBROSIS
(1968-06)ENDONYOCARDIAL FIBROSIS (E.M.F) is a common heart disease in certain areas of Africa. Much knowledge has accumulated in recent years about the pathology and clinical features of this disease; but at present, its pathogenesis ... -
THE ROLE OF KUPFFER CELLS IN ETHANOL AND AFLATOXIN B₁-INDUCED p53 GENE MUTATION IN HEPATOCARCINOGENESIS
(2009-06)Kupffer cells (KC) play an important role in hepatic homeostasis, and in acute and chronic response of the liver to endotoxins. The KC also mediate the release of cykokines and reactive oxygen species (ROS) involved in ... -
THE ROLE OF OXIDATIVE STRESS IN BIOCHEMICAL, SEMINOLOGICAL AND HISTOLOGICAL CHANGES DURING ACUTE ADMINISTRATION OF ARTEMETHER
(2010)Artemether is an antimalarial drug which is effective in the treatment of multidrug resistant malaria but also induces oxidative stress in tissues. Limited information is available on role of oxidative stress in tissue ... -
THE ROLE OF RODENT AND HUMAN FACTORS IN THE PREVALENCE OF ANTIBODY TO LASSA VIRUS IN NIGERIA AND SIERRA LEONE
(1996-03)Studies were conducted on distribution of Lassa fever (LF), a viral haemorrhagic disease in humans, in Nigeria and Sierra Leone and presence of Lassa virus (LV) in rodents as it relates to human infection, using the Enzyme ... -
THE ROLE OF THE GASTROINTESTINAL TRACT IN GLUCOSE HOMEOSTASIS
(1992-06)This study was designed to investigate the role of the gastrointestinal tract in glucose handling during hyperglycaemia induced by infusion of glucose, injection of glucagon or adrenaline and during insulin -induced ... -
SELECTED GENETIC RED-CELL MARKERS AND THE EPIDEMIOLOGY OF CHLOROQUINE-ASSOCIATED PRURITUS IN NIGERIA
(1994-02)Anecdotal reports suggest that there may be a familial component to Chloroquine-associated pruritus (CAP). To test this hypothesis, the epidemiology of CAP was studied with respect to hemoglobin S (HbS) and glucose-6-phosphate ... -
SOME CHARACTERISTICS OF Bartonella henselae AN OPPORTUNISTIC PATHOGEN IN ACQUIRED IMMUNE DEFICIENCY SYNDROME
(1997-12)Cat-scratch disease (CSD) is an infectious disease, implicated as an opportunistic infection in human immunodeficiency virus (HIV) patients. So far, Bartonella henselae (Rochalimaea henselae), remains the most acceptable ... -
SOME IMMUNOLOGICAL PARAMETERS AS INDICES OF AGING IN NIGERIANS
(1994-02)This study involved 541 participants. It assessed the state of body defence mechanisms during ageing in 217 healthy Nigerians aged 6-95 years. A different group of 274 healthy subjects of ages 6 to 60 years were studied ...