Browsing Faculty of Basic Medical Sciences by Title
Now showing items 94-113 of 153
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THE INTRINSIC ANATOMICAL ORGANIZATION OF THE CUNEO-GRACILE NUCLEI COMPLEX OF THE RAT
(1977-02-23)The studies making up the thesis were aimed towards elucidating the intrinsic structural organization of the cuneo-gracile nuclei complex. The rat was the experimental animal of choice but limited data were collected from ... -
AN INVESTIGATION OF MECHANISM OF AMPICOGULANT ACTION OF AFLATOXIN IN SOME ANIMAL SPECIES
(1970-06)It has been reported that aflatoxin B₁ isolated from foodstuff contaminated with a toxin strain of Aspergillus Flavus produces in rats a lesion similar to the “sweet clover disease”. Biochemical, Kinetic and microscopic ... -
INVESTIGATIONS INTO CHANGES IN PLATELET FUNCTION IN EXPERIMENTAL MALARIA
(1985-08)In this thesis the problem of haemostatic disorders with particular reference to platelet dysfunction in experimental malaria models has been examined. In the Swiss albino mouse model infected with Plasmodium berghei (P. ... -
THE ISOLATION AND CHARACTERIZATION OF PORCINE ERYTHROCYTE Ca2+ - ADENOCINE TRIPHOSPHATASE
(1985-10)The Ca2+- pumping adenosine triphosphatase, Ca2+-ATPase, (ATP phosphohydrolase, EC 3.6.1.3), was purified from porcine erythrocyte membranes by calmodulin affinity chromatography in the presence of phosphatidylcholine and ... -
LANDFILL LEACHATE-INDUCED OXIDATIVE DAMAGE IN RAT AND AFRICAN CATFISH
(2014-06)Landfill leachate poses potential health hazards for man and his environment. Leachates can generate free radicals in exposed tissues. Free radicals may cause DNA damage and oxidative stress associated with many disease ... -
MAGNESIUM METABOLISM IN DIABETES MELLITUS AND THE EFFECTS OF MAGNESIUM ADMINISTRATION ON PLASMA GLUCOSE AND INSULIN LEVELS
(1995-09)Magnesium plays an important role in human metabolic activities. Its role in glucose metabolism is well established. However, there are still some conflicting views on the altered magnesium homeostasis in diabetic states ... -
MALARIA PARASITAEMIA AND HUMORAL IMMUNE RESPONSES TO SOME DEFINED PLASMODIUM FALCIPARUM ANTIGENS IN NEWBORNS, INFANTS AND ADULT NIGERIANS
(1994-08)A cohort of mothers and their newborns at Igbo-Ora, Oyo state was studied longitudinally for 12 months to determine the incidence of malaria parasitaemia, episodes of clinical malaria and their humoral immune response to ... -
MECHANISM OF ANTI-DIABETIC ACTIVITIES OF Musa sapientum LEAF EXTRACT IN RATS TREATED WITH ALLOXAN
(2014)Diabetes mellitus results from necrosis of pancreatic β-cell and insulin resistance at the cellular level. Musa sapientum has been shown to possess anti-diabetic properties. However, the mechanism of its action is unknown. ... -
MECHANISM OF ANTI-GASTRIC ULCER EFFECT OF BETULINIC ACID IN MALE ALBINO RATS
(2011-03)Betulinic acid (BA) is a lupane-type triterpene that has been identified and isolated from different plant species used in ethnomedicine worldwide. It is known to possess anti-ulcer, anti-tumor and anti-microbial properties. ... -
MECHANISMS OF THE ANTI-GASTRIC ULCER ACTIVITY OF RISPERIDONE IN MALE RATS
(2015-02)Gastric ulcer and its treatment is a global problem, thus the search for a novel drug becomes a continuous one. Risperidone, though, anti-psychotic has been found to exhibit anti-ulcer activity, however, its mechanisms of ... -
METABOLISM OF LIPIDS IN KWASHIORKOR
(1969)A study of lipid metabolism in Nigeria kwashiorkor children has shown that the serum phospholipids, total cholesterol, cholesterol esters and total fatty acid levels were low when compared with the values for control ... -
MODULATING EFFECT OF POLYCLONAL ANTIBODIES AGAINST AFLATOXIN B₁ MACROMOLECULAR COMPLEXES ON AFLATOXIN INDUCED HEPATOCARCINOGENESIS
(1990-11)Polyclonal immunoglobulin G antibodies were raised in adult male albino rabbits against aflatoxin B₁-bovine serum albumin, aflatoxin B₁-histone H₁ and aflatoxin B₁-microsomal proteins complexes after a single intradermal ... -
THE MODULATION OF RAT LIVER MICROSOMAL CALCIUM ION-PUMPING ATPase BY DICOPHANE AND LOW PROTEIN INTAKE
(1992-05)The effect of the liver tumour promoter, dicophane, with those of low protein intake (LPI) in the functional expression of rat liver microsomal Ca²⁺-ATPase were compared. The effects of dicophane and LPI on the activity ... -
MOLECULAR CHARACTERIZATION OF IMPROVED CASSAVA CULTIVARS AND COMMONLY GROWN NIGERIAN LANDRACES USING SIMPLE SEQUENCE REPEAT MARKERS
(2004-02)Cassava is a starchy staple food of tropical Africa whose yield is affected by several biotic stresses. Improved cassava cultivars that are resistant to biotic stresses were developed to boost cassava production. Also, ... -
NEUROBEHAVIOURAL AND NEUROPROTECTIVE EFFECTS OF KOLAVIRON IN LABORATORY RODENTS
(2017-06)The high cost of orthodox medicines and their attendant side effects in some cases make the search for an effective and affordable alternative imperative. Kalaviron, a complex biflavanoid from Garcinia kola seeds, possesses ... -
NITROSAMINE CONTAMINATION OF SOME NIGERIAN BEVERAGES
(1976-09)N-Nitrosamines are amongst the most potent and versatile experimental carcinogens ever tested on laboratory animals. As a result, their presence and that of their precursors in food meant for human consumption is a possible ... -
NITROSAMINE CONTAMINATION OF SOME NIGERIAN INDIGENOUS BELIEVES
(1972-12)The possible role of carcinogenic nitrosamines in the aetiology of human cancer has been discussed by experts (O. Basslr, Pers. Comm.; Eisenbrand et al, 1969; Lijinakcy and Epstein, 1970). As a result of this apprehension ... -
THE NUTRIENT COMPOSITION OF SOME NIGERIAN LEAFY GREEN VEGETABLES AND PHYSIOLOGICAL AVAILABILITY OF THEIR IRON CONTENT
(1977-04)Ten leafy green vegetables, commonly incorporated into diets by peasants of the Cross River State of Nigeria, have been analyzed for their various nutrient contents. The vegetables were Abelmoschus esculentus, Corohorus ... -
THE NUTRIENT COMPOSITION OF SOME NIGERIAN LEAFY GREEN VEGETABLES AND PHYSIOLOGICAL AVAILABILITY OF THEIR IRON CONTENT
(1973-02)ABSTRACT In order to investigate the potential usefulness of local foodstuffs in Nigeria, a comprehensive survey of the various nutrients in 10 local vegetables was carried out. The survey covers: total nitrogen and total ... -
NUTRITIONAL CHANGES IN SOME NIGERIAN FOODS DURING DIETARY PREPARATION AND THEIR EFFECTS ON THE MAMMALIAN BODY
(1967-06)Starting with a comprehensive review of the research already done in the related field of nutrition, the chemical composition of 20 Nigerian food materials which are used in the preparation of six common local diets has ...