Browsing Faculty of Basic Medical Sciences by Title
Now showing items 80-99 of 153
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HISTOCHEMISTRY OF RAT SMALL INTESTINE MUCOSA AFTER ORAL ADMINISTRATION SILVER NITRATE
(1979)The investigations making up the thesis were aimed towards elucidating the structural and histochemical effects of toxic doses of silver nitrate on rat small intestinal mucosa at three different sites. The studies were ... -
HORMONE AND DRUG STIMULATION OF TESTOSTERONE SECRETION IN THE RAT LEYDIG CELL
(1995-07)The steroidogenic response of rat Leydig cell to gonadotrophin and prolactin was used to modify an in vitro experimental model for studies an the effect of some medicinal extracts on testosterone secretion. The crude ... -
HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 SEROTYPES AND SOME ASPECTS OF PHENOTYPIC PROPERTIES OF THE VIRUS ISOLATES IN NIGERIA
(1999-08)Human Immunodeficiency Virus (HIV) is a retrovirus aetiologically and epidemiology associated with the Acquired Immunodeficiency Syndrome (AIDS). The prevalence of HIV infection and the disease and incidence of AIDS are ... -
HUMAN LOIASIS IN WESTERN NIGERIA
(1974-07)An attempt has been made in this study to bridge some of the gaps in our knowledge of loiasis in Western Nigeria. At this same time, areas for future research which might lead to a better understanding of the disease ... -
HYPOLIPIDAEMIC, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF Persea americana (Lauraceae) LEAF EXTRACTS IN RATS)
(2010-05)Hyperlipidaemia and oxidative stress are important factors in the pathogenesis of chronic degenerative and inflammatory diseases. Persea americana (Lauraceae) has been widely used in ethnomedicine in the treatment of various ... -
IMMUNOCHEMICAL STUDIES ON THE ANTIGENE OF PLASMODIUM FALCIPARUM MALARIA
(1971-12)ABSTRACT In a previous thesis, the study of certain aspects of the immune response of man to Plasmodium falciparum malaria in Ibadan, Nigeria were investigated. An attempt was made for the search of a suitable source of ... -
IN VITRO ABSORPTION AND METABOLISM OF SOME NATURAL ESTROGENS IN RAT INTESTINE
(1980-09)In vitro intestinal absorption and metabolism of two natural estrogens, estradiol and estrone sulphate,were studied and compared using uneverted sacs from different segments of the rat intestine. Absorption was measured ... -
THE INFLUENCE OF CHLOROQUINE PHOSPHATE ON MALE REPRODUCTIVE FUNCTIONS
(1991-09)The influence of Chloroquine phosphate on Male reproductive functions in the adult and pre-pubertal rats was studied. Chloroquine phosphate dissolved in distilled water was administered intraperitoneally daily to the rats ... -
INFLUENCE OF FREE RADICAL -MEDIATED MEMBRANE DAMAGE ON ERYTHROCYTE Ca²⁺-HOMEOSTASIS IN CERTAIN PATHOLOGICAL STATES
(1990-11)The possible nature of toxic oxygen from radical species generated in vivo under pathological conditions as well as the relationship between oxygen free radicals and/or lipid peroxidation and the abnormal regulation of ... -
INHIBITION OF HUMAN HAEMOGLOBIN GLYCOSYLATION BY FLAVONOIDS CONTAINING METHANOLIC EXTRACTS OF THE LEAF OF Cnestis ferruginea
(2002-10)Protein glycosylation by a sugar adduction, an oxidative process is exemplified by the glycosylation of haemoglobin A. The objective of this study, therefore, is to assess the influence of the leaf extracts of Cnestis ... -
INSULIN SECRETION AND SENSITIVITY IN FIRST-DEGREE RELATIVES OF NIGERIAN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM)
(1992-02)The blood insulin and glucose concentrations were analysed before and during frequently sampled intravenous glucose tolerance tests (FSIGT) In 2 groups of Nigerian subjects: (1 ) Control group (n=18), without a positive ... -
INSULIN SECRETION IN NON-OBESE NIGERIANS (effect of glucose, sulphonylureas and weight reduction
(1974-07)Protein calorie malnutrition in man and experimental animals produces striking changes in the pancreas; and clinically, protein deficiency has been shown to diminish exocrine pancreatic secretions in addition to the ... -
INTERACTION OF PROSTAGLANDIN E2(PGE2) WITH NORADRENARINE AND ITS ANTAGONISTS IN THE ISOLATED MESSENTRIC ARTERY OF RAT
(1980-07)The effect of PG32, PGF2a- and PGI2, on vasoconstriction induced by different mechanisms was studied in the isolated rat mesenteric artery as described by McGregor (1965). Vasoconstriction was induced by mechanisms involving ... -
INTESTINAL HAEMODYNAMICS AND GLUCOSE UPTAKE FOLLOWING HEXOSES ADMINISTRATION IN DOGS
(2012-04)An increase in blood glucose levels has been reported to induce a rise in Intestinal Glucose Uptake (IGU) through reduction in Intestinal Vascular Resistance (IVR) and increase in Intestinal Blood Flow (IBF). However, ... -
THE INTRINSIC ANATOMICAL ORGANIZATION OF THE CUNEO-GRACILE NUCLEI COMPLEX OF THE RAT
(1977-02-23)The studies making up the thesis were aimed towards elucidating the intrinsic structural organization of the cuneo-gracile nuclei complex. The rat was the experimental animal of choice but limited data were collected from ... -
AN INVESTIGATION OF MECHANISM OF AMPICOGULANT ACTION OF AFLATOXIN IN SOME ANIMAL SPECIES
(1970-06)It has been reported that aflatoxin B₁ isolated from foodstuff contaminated with a toxin strain of Aspergillus Flavus produces in rats a lesion similar to the “sweet clover disease”. Biochemical, Kinetic and microscopic ... -
INVESTIGATIONS INTO CHANGES IN PLATELET FUNCTION IN EXPERIMENTAL MALARIA
(1985-08)In this thesis the problem of haemostatic disorders with particular reference to platelet dysfunction in experimental malaria models has been examined. In the Swiss albino mouse model infected with Plasmodium berghei (P. ... -
THE ISOLATION AND CHARACTERIZATION OF PORCINE ERYTHROCYTE Ca2+ - ADENOCINE TRIPHOSPHATASE
(1985-10)The Ca2+- pumping adenosine triphosphatase, Ca2+-ATPase, (ATP phosphohydrolase, EC 3.6.1.3), was purified from porcine erythrocyte membranes by calmodulin affinity chromatography in the presence of phosphatidylcholine and ... -
LANDFILL LEACHATE-INDUCED OXIDATIVE DAMAGE IN RAT AND AFRICAN CATFISH
(2014-06)Landfill leachate poses potential health hazards for man and his environment. Leachates can generate free radicals in exposed tissues. Free radicals may cause DNA damage and oxidative stress associated with many disease ... -
MAGNESIUM METABOLISM IN DIABETES MELLITUS AND THE EFFECTS OF MAGNESIUM ADMINISTRATION ON PLASMA GLUCOSE AND INSULIN LEVELS
(1995-09)Magnesium plays an important role in human metabolic activities. Its role in glucose metabolism is well established. However, there are still some conflicting views on the altered magnesium homeostasis in diabetic states ...